The Anticancer Potential of Turkey Tail / Coriolus Versicolor Mushroom

Researched and written by Keith Bishop, Clinical Nutritionist, Cancer Coach, and Retired Pharmacist

Coriolus versicolor, or Turkey Tail, is a medicinal mushroom extensively studied for its potential anticancer properties. Used in traditional Chinese medicine for centuries, modern research has uncovered its ability to support immune function and complement conventional cancer treatments.

Alternative Names: Trametes versicolor, Polyporus versicolor, Polystictus versicolor, multicolored polypore mushroom

Common Names and Ingredients: PSK (protein-bound polysaccharide), PSP, VPS, Turkey Tail, Yun Zhi, Kawaratake, and Krestin.

Where Does Coriolus Versicolor Grow?

Coriolus versicolor is a saprotrophic fungus that grows on decaying hardwood trees worldwide. It is commonly found in Asia, Europe, and North America, thriving in moist, wooded environments. In China, it is often cultivated for medicinal use.

Active Ingredients

The key bioactive compounds in Coriolus versicolor include:

• Polysaccharide-K (PSK) – Known as Krestin, this compound is widely used in Japan as an adjunct cancer therapy.
• Polysaccharide Peptide (PSP) – In Chinese formulations, PSP has immunomodulatory effects.
• Beta-glucans – These polysaccharides enhance immune response.

Available Supplements

Coriolus versicolor is available in various forms, including:

• Capsules and tablets – Standardized extracts containing PSK or PSP.
• Powders – Used for teas or mixed into food.
• Liquid extracts – Concentrated tinctures for easy consumption.

How to Brew Coriolus Versicolor Tea

Brewing tea from Coriolus Versicolor is a simple way to consume its beneficial compounds:

1. Boil water to around 208°F (98°C).
2. Add dried mushroom slices or powder to the water.
3. Simmer for 30–60 minutes to extract polysaccharides.
4. Strain and enjoy. You can add honey or ginger for taste.

Impact on Cancer Treatments

Clinical trials have reported both the indirect anti-cancer properties of CV through immuno-stimulating mechanisms and its direct anti-cancer activity, leading to the adoption of CV compounds as an adjunct therapy for cancer treatment in Japan and China.

Chemotherapy

Studies suggest that PSK and PSP may enhance chemotherapy efficacy by boosting immune function and reducing side effects. Some trials indicate improved survival rates when combined with chemotherapy.

Radiation Therapy

Coriolus versicolor has been studied for its ability to reduce radiation-induced side effects, such as fatigue and immune suppression. However, more research is needed to confirm its effectiveness.

Immunotherapy

PSP has been shown to modulate immune responses, potentially enhancing the effects of immunotherapy. It may help overcome tumor-induced immune suppression.

Other Health Benefits

Beyond cancer support, Coriolus versicolor offers additional health benefits:

• Boosts immune function by stimulating natural killer cells.
• Supports gut health by promoting beneficial bacteria.
• Reduces inflammation, which may help with chronic diseases.

Potential Side Effects

While generally safe, some individuals may experience:

• Digestive discomfort such as nausea or diarrhea.
• Allergic reactions, including skin irritation.
• Interactions with medications, particularly immunosuppressants.

• Dark colored stool (poop)
• Darkening of fingernails

Conclusion

Coriolus versicolor is a promising natural supplement with anticancer properties, immune-boosting effects, and additional health benefits. While research supports its use alongside conventional treatments, consulting a healthcare provider before incorporating it into a regimen is essential.

Reference Sources

Stošić-Grujičić, S., Mijatović, S., Maksimović-Ivanić, D. (2011). An Evidence-based Perspective of Coriolus Versicolor (Multicolored Polypore Mushroom) for Cancer Patients. In: Cho, W. (eds) Evidence-based Anticancer Materia Medica. Evidence-based Anticancer Complementary and Alternative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0526-5_13

Awadasseid A, Hou J, Gamallat Y, Xueqi S, Eugene KD, Musa Hago A, et al. (2017) Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus Versicolor. PLoS ONE 12(2): e0171270. https://doi.org/10.1371/journal.pone.0171270

Jędrzejewski T, Sobocińska J, Maciejewski B, Slovakova M, Wrotek S. Enhanced Anti-Cancer Potential: Investigating the Combined Effects with Coriolus versicolor Extract and Phosphatidylinositol 3-Kinase Inhibitor (LY294002) In Vitro. International Journal of Molecular Sciences. 2025; 26(4):1556. https://doi.org/10.3390/ijms26041556

Memorial Sloan Kettering Cancer Center Overview: https://www.mskcc.org/cancer-care/integrative-medicine/herbs/coriolus-versicolor

Nakazato H, Koike A, Saji S, Ogawa N, Sakamoto J. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet. 1994;343(8906):1122-1126. doi:10.1016/s0140-6736(94)90233-x https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(94)90233-X/fulltext