Researched and written by Keith Bishop, Cancer Coach, Clinical Nutritionist, Retired Pharmacist

D-mannose, a simple sugar, has been studied for its potential anti-cancer actions. Below, we explore its mechanisms, effects on cancer treatments, and considerations for its use based on scientific research. Mannose cancer research is in the early stages and limited to laboratory cancer cell studies, a few animals, and even fewer human studies.

The Warburg Effect and D-Mannose

The Warburg effect is where cancer cells rely heavily on glycolysis (glucose) for energy production, even in the presence of oxygen. Research indicates that D-mannose can disrupt glycolysis, affecting the Warburg effect and reducing cancer cell proliferation. A study published in Nature Nature link shows how D-mannose interferes with glucose metabolism, impairing tumor growth.

D-Mannose's Impact on Glucose Metabolism

D-mannose alters glucose metabolism by inhibiting pathways like the pentose phosphate pathway, wh...