The Anticancer Actions of IV Vitamin C: Mechanisms, Dosing, Safety Labs, and Integration with Oncology Care

Researched and written by Keith Bishop, Clinical Nutritionist, Cancer Coach, and Founder of Prevail Over Cancer™, and the Prevail Protocol™

High-dose intravenous vitamin C (IVC) has reemerged as a promising adjunctive therapy in integrative oncology. Modern research highlights its unique pharmacology, potential anticancer mechanisms, and its ability to support patients undergoing chemotherapy, radiation, and immunotherapy. This guide breaks down the science, dosing considerations, safety labs, and clinical integration—supported by peer-reviewed medical literature.

What Makes IV Vitamin C Different From Oral Vitamin C?

Oral vitamin C absorption is tightly limited by intestinal transporters, which cap blood levels even at high doses. In contrast, IV administration bypasses intestinal absorption and produces blood concentrations 100–500× higher than those required for a...